Another Negro League great, Satchel Paige is thought of to be one of the greatest pitchers of all time and is my personal favorite but was still not allowed to play in the Major Leagues because of the color of his skin.
He was so good that the owner of the Yankees would set up exhibition games against his Negro League team during the off season and it would not be uncommon for him to strike out double digit amounts of the Bronx Bombers in a single start during the days of Murderer's Row which featured hall of famers like Joe DiMaggio, Babe Ruth, and Yogi Berra.
There is even a rumor that on one start a member of the Yankees began to heckle him from the dugout doubting his pitching abilities so as a response Paige called time out and told every member of the defense other than the catcher to go back to the dugout. He then proceeded to strike out the next three batters in order so as to prove a point that he didn't even need the help of his defense because of the caliber of his pitching.